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Research suggests the use of vitamin B12 supplements in those with kidney disease and a B12 deficiency, but fully understanding the risks and benefits of regular supplemental B12 in those without a deficit still requires more research

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Because these compounds work through different pathways, you don't necessarily have to take them at the exact same second, but they should both be part of your daily rhythm for the best results

Citrulline is a precursor to arginine, and so may be beneficial for those with anemia as well