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The results are consistent with the notion that domain II, which harbors most of the variability in primary structure, plays a crucial role in defining the substrate specificity of class mu isoenzymes

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Differences in the analytical methodology may also affect the measured folate content 41,56,98,106,174,175,176,177,178,179,180,181,182,183

901 The DNA sequence of NOX4 contains iron-responsive element-like (IRE-like) sequences that typically bind to iron-regulatory protein 1 (IRP1)

doi: 10.3389/fnagi.2025.1665957 Received 14 July 2025 Accepted 25 September 2025 Published 10 October 2025 Volume 17 - 2025 Edited by Indrani Poddar, University of Minnesota Twin Cities, United States Reviewed by Shikha Grover, Dyne Therapeutics, United States Ayush Kumar Srivastava, SUNY Potsdam, United States Updates Copyright 2025 Invernizzi, Ciocca, Contaldi, Inverso, Calandrella, Mignone, Barichella, Isaias and Pezzoli