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It has negligible systemic toxicity and has been administered in humans at high dosages (up to 12 g/day for 3 months) without significant adverse effects (Ma et al., 2019)

Los ensayos clnicos SURMOUNT han demostrado prdidas de peso promedio del 15-21% del peso corporal inicial con la dosis ms alta de tirzepatida (15 mg semanales) durante 72 semanas, representando uno de los tratamientos farmacolgicos ms efectivos disponibles actualmente

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Moreover, the activation of Sat1 has been shown to promote lipid peroxidation, rendering cells more susceptible to oxidative stress and contributing to the development of ferroptosis ( In this study, the induction of ferroptosis in MIRI was observed