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Nevertheless, treatment efficacy has been hindered by restricted tissue penetration depth and the inadequate performance of conventional transducers and photosensitizers

Consequently, Epigenetic modifications, encompassing DNA methylation, histone alterations, and non-coding RNA interactions, intricately regulate gene expression, playing a pivotal role in HPV-induced carcinogenesis by modulating oncogene expression, DNA repair processes, and immune evasion strategies

Thus, organoids have provided insights into the complex pathophysiology of MELAS, indicating that neurodevelopmental defects are intrinsic to MELAS

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EV engineering strategies: targeted modification and gene editing