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Because sodium is the main driver of fluid volume outside cells, sodium-containing IV fluids keep water in the space where blood volume and tissue perfusion depend on it

Finally, when present at a high enough concentration, RNOS irreversibly binds to Fe (II) from heme, resulting in the removal of heme from proteins and depletion of Fe in cells

1c) and, as expected, sensitized T98G cells to H 2 O 2 -induced cell death (Fig