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Curcumin mediates glutathione depletion via metalorganic framework nanocarriers to enhance cisplatin chemosensitivity on esophageal cancer Discover Nano Springer Nature Link Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms Topical glutathione amino acid precursors protect skin against environmental and oxidative stress Cui 2024 Journal of the European Academy of Dermatology and Venereology Wiley Online Library Multi Omics Analysis Reveals Chronic Cisplatin Exposure Is Associated with Metabolic Rewiring Toward Glutathione Metabolism to Support Redox Adaptation in High Grade Serous Ovarian Cancer Metabolic orchestration driven by GGCT: diverting glutamine to glutathione biosynthesis while enhancing glucose anaplerosis for tumor proliferation Cell Death & Disease

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Importantly, these potential off-target effects do not negate our overall conclusion regarding the pivotal involvement of LRP6 in the pathological process

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The two pathways can counteract the upregulation of the cellular FLICE inhibitory protein, an antiapoptotic protein, which defers cell death and benefits SARS-CoV-2 replication (37, 38)

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It holds this title because it is found in high concentrations in nearly every cell

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