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doi: 10.3390/ijms19041264 31 WoolardJBevanHSHarperSJBatesDO

Aslan M, Thornley-Brown D, Freeman BA

The mechanism appears to involve increased serotonin synthesis in substantia nigra, a regional pattern unlike any existing antidepressant drug

Cytoplasmic NADPH generation from the CPS relies upon cytoplasmic ACLY metabolizing CoA and mitochondrial-exported citrate for the generation of oxaloacetate and acetyl-CoA