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Betaine protection is mediated via donating a methyl group in methionine metabolic pathway to remove homocysteine and SAH and preserves cellular methylation potential, thereby safeguarding the gut microbiota and intestinal barrier function

Previous studies indicate that plants activate antioxidant systems to cope with oxidative and osmotic stress conditions [47]

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An endogenous stimulus can be pH, redox conditions, or reactive oxygen species (ROS) (Figure 1)

At sacrifice, selected tissues (liver, kidney, skin, muscle, and bone) were collected, weighed and counted for radioactivity