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Vitamin D may also act through VDR to lower microbial dysbiosis and improve intestinal barrier function with a rise in SCFA production by commensal bacteria

215 Therefore, in diabetic osteoporosis, factors such as high blood sugar jointly cause abnormal expression of BMAL1 and inhibition of HIF-1 function, disrupting the crucial BMAL1-HIF-1 communication

Exogenous ROS-Induced Killing Depends on a Variety of Innate Mechanisms Exogenous ROS, as an antimicrobial weapon wielded by phagocytes, are generated from NADPH oxidase (NOX2) in response to microbe recognition (Panday et al., 2015)

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