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In their study, Sprague Dawley rats were intraperitoneally injected with Mn chloride (25 mg/kg body weight) every 48 h for 3 months to mimic Mn overexposure

The amine and thiol functional groups of the SBA-15 MSN were examined using FTIR analysis (Fig

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suggested that intraperitoneal injection of extracellular cold-inducible RNA-binding protein (eCIRP) reduced the expression of GPX4 in lung tissue and increased lipid ROS, while ferrostatin-1 treatment significantly reduced this increase [68]

This indicates that augmenting the function of missing beneficial microbes can tip the immune balance toward regulation rather than autoimmunity