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Change history 16 November 2011 This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication References Birkmayer W, Riederer P, Youdim M, Linauer W (1975) Potentiation of the anti-akinetic effect of L-dopa treatment by an inhibitor of MAO-B, deprenyl

Conclusions Multiple intracellular and extracellular mechanisms are the root of drug resistance and relapse in AML stem cells, and influence the dormancy, resistance to apoptosis and senescence, epigenetic modification, metabolic reprogramming, and protection of the BM microenvironment