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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

The operative note must document which components were exchanged

As a transmembrane glycoprotein with receptor-mediated adhesion function and ectoenzymatic activity, CD38 is ubiquitously expressed on MM cells, as well as some regulatory T cells (Tregs) and natural killer (NK) cells [5, 6]