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Furthermore, there was noted, that Cer propagates the dissociation of Beclin1 from the Beclin1/Bcl-2 complex, which is a prerequisite for Beclin1-VPS34-VPS15 formation [62]

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Paradoxically, both mTORC1 inhibition by rapamycin and silencing of Rheb reverse this effect in TSC2 -null cells, sending TFEB back to the cytoplasm and promoting its re-phosphorylation by mTORC1, for which the latter event appears to be controlled by the Rags [101]

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