oral melanotic macule lip macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial Melanotic Macule On Lip

Renal Histopathology The paraffin-embedded kidneys were cut in 3-m-thick slices for hematoxylin and eosin (H&E) and Periodic acid-Schiff (PAS) staining to evaluate the histopathologic injury

Assays of protein packaging efficiency Dialyzed EP-LNPs were concentrated and washed free of unbound protein by centrifugation at 6000 x g for ~60 min at 4 o C through a 300,000 MWCO VIVASPIN 2 spin filter (Sartorius #VS0251)

determined by author and by software (PISA,PQS) Molecular Components in 3GRS Label Count Molecule Proteins (2 molecules) A A_1 2 Glutathione Reductase (Gene symbol: GSR ) Chemicals and Non-standard biopolymers (4 molecules) 1 2 PHOSPHATE ION 2 2 FLAVIN-ADENINE DINUCLEOTIDE * Click molecule labels to explore molecular sequence information

Homozygous Allelic disorders SPG74 SPOAN phenotype Necrotizing myelopathy in dogs IBA57 protein Biosynthesis of mitochondrial iron-sulfur [4Fe-4S] proteins Clinical Onset Age: Prenatal to 2 years May be Subacute Associated with: Infection or Vaccination CNS Hypotonia & Impaired motor function: Generalized Psychomotor regression Intellectual disability Spasticity Epilepsy (30%) Feeding difficulty Respiratory insufficiency Arthrogryposis Microcephaly Course Progresseive or Episodic worsening Death: Perinatal to Later childhood in some Laboratory CSF & Serum Lactate: High Muscle IBA57 protein: Reduced Complex I & II: Reduced Brain MRI Malformations White matter pathology Hyperglycinemia IBA57 Variant syndrome: Spastic paraplegia 74 (SPG74) Epidemiology: 11 patients with SPOAN-like syndromes Genetics Inheritance: Recessive Mutation: Slice site, Homozygous

"Plasma terminal half-life" (PDF)