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The flask fermentation results showed that ectoine titers of ET09 ( ectA : ectB : ectC = 2:1:1) and ET10 ( ectA : ectB : ectC = 3:1:1) were 6.85 g/L and 2.39 g/L lower than that of ET08 ( ectA : ectB : ectC = 1:1:1), respectively (Figure 5A)

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82 Besides, drug-induced ROS can inhibit the PI3K/AKT pathway to suppress cancer cell proliferation by disrupting key pathways critical for tumor growth and survival, as evidenced by studies with (+)-anthrabenzoxocinone in NSCLC and 6-methoxydihydrosanguinarine in breast cancer