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Digestive effects seem rare with injectable administration but occasionally reported

Although oral semaglutide might be a better option for patients who are allergic to injections or reluctant to self-inject, its efficacy may be limited by its stringent administration guidelines, which call for taking it half an hour before the first meal, drink, or other medication [90]

Why it fails for multi-dose peptide vials: Once the seal is punctured, there's no preservative inhibiting bacterial growth