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Phase 2 trials produced an average of 24.2% body weight reduction at the 12mg dose over 48 weeks

Serious complications are uncommon but should be reported promptly to a clinician

The experimenter was not blinded to treatment conditions during data collection and analysis due to the obvious differences in phenotype between differently treated primary cultures

While some studies have shown stable PLN phosphorylation levels in the myocardium of mice older than 2 years compared to those younger than 6 months [19] , other research observed a significant reduction in PLN phosphorylation in heart homogenates from 2-year-old rats relative to 6-month-old rats [25]

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