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Additional studies are needed to confirm the potential benefit of L-carnitine in the management of cellulite

142 Cocaine blocks sodium channels and prolongs the QRS complex in a manner similar to Class IA antidysrhythmic agents and tricyclic antidepressants

In humans, MTs are structurally encoded by a family of genes located on chromosome 16q13, comprising at least 11 functional members: the MT1 genes consist of 18 isoforms, including 10 functional genes ( MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1M, and MT1X ) and 8 pseudogenes ( MT1CP, MT1DP, MT1JP, MT1L, MT1LP, MT1XP1, MT1P3, and MT1P1 ), in addition to MT2 (also known as MT2A), MT3 , and MT4 55,119 (Fig

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Similarly, magnoflorine (Mag), a natural alkaloid, enhanced DOX sensitivity in breast cancer by augmenting DNA damage, inducing cell cycle arrest, promoting apoptosis, and facilitating autophagy through PI3K/AKT/mTOR inhibition and p38 MAPK activation, with in vivo models validating significant anti-tumor efficacy and diminished systemic toxicity (148)