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Discovery and validation of biomarkers using omics technologies The goal for new predictive translational safety biomarkers is to be able to monitor early indications of organ toxicity in clinical trials, so better informed clinical and regulatory decisions can be made and treatment can be stopped or altered before organ injury occurs (Aronson 2005

Gene abundance of fecal metagenomes for B-GUS and GDH activities To investigate the distribution of b-gus and gdh in fecal metagenomes, we reanalyzed metagenomes of healthy donors ( n = 103), and of CRC state I-IV patients ( n = 53) of previously generated datasets from a French cohort [25]

These compounds can influence gene expression and cellular repair, effectively slowing the biological clock

Glc-Blanariu GE, Diaconescu S, Ciocoiu M, Tefnescu G (2018) New insights into the role of trace elements in IBD

It is an important cofactor in the hydroxylation of proline to 4-hydroxyproline and lysine to 5-hydroxylysine, which accounts for 25% of the collagen structure composition