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No mice receiving indomethacin and esomeprazole died, but the death rate while receiving indomethacin was 38% ( 2 , P = 0.05)

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The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases

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