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Description

Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas

Preclinical toxicological data: Acute and subacute toxicity studies in rats did not reveal any mortality or significant organ toxicity, even at doses well above therapeutic doses (up to 100 times the effective dose)

Lutein treatment effectively decreased ROS, thus facilitating the reduction of rhodopsin levels, and the up regulation of glial fibrillary acidic protein (GFAP) expression