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Pieper emphasized that currently available over-the-counter NAD+ precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer. This conclusion extrapolates beyond the published findings and lacks support from human clinical evidence

[144] [166] This is the opposite of pathological stimulant use, which induces decreased striatal DRD2 density

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The primary formed radical is the superoxide radical anion (O 2 - ) in the mitochondrial matrix, which is dismutated by Mn-SOD (SOD2) (Lambert and Brand, 2009[260])

doi: 10.1002/cmdc.201500486 189 ShenY.TakahashiM.ByunH.-M.LinkA.SharmaN.BalaguerF.et al