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Int Immunopharmacol Deficiency of the innate immune protein IFITM3 impairs phagocytosis and promotes autism-like behaviors in mice

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This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation

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In addition, antibiotics can alter the abundance and diversity of the intestinal flora by indirectly affecting oxidative stress in the gut [61], which provides evidence that oxidative stress affects the intestinal flora in one way or another