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Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration

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Gas introduced into the venous system of the lungs by pulmonary barotrauma will not be trapped in the alveolar capillaries and will consequently be circulated to the rest of the body through the systemic arteries, with a high risk of embolism

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After 4 weeks, the treatment groups MMSE scores didnt improve more from baseline than did the placebo groups