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In our opinion, the increase in hydrogen sulfide production in glutathione-treated old animals was due to an increase in the expression of 3-MST (by 25%), or probably the activity of this mitochondrial enzyme due to an excess of the substrate L-cysteine, which is common for the synthesis of this gaseous mediator and glutathione

Therefore, to combat the decline of glutathione, supplementation becomes a resort to achieve healthy skin

However, the magnitude of behavioral improvement varied across studies, likely reflecting differences in disease models, treatment duration, and formulation characteristics

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