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"Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis"

[PubMed: 14715515] 106

Reduced cobalamin availability leads to: Impaired enterocyte regeneration Villous atrophy and barrier dysfunction Increased intestinal permeability Secondary dysbiosis and chronic inflammation Clinically, this manifests as: Persistent anorexia Weight loss Chronic diarrhea Poor response to standard GI or pancreatitis therapy Low vitamin B12 concentrations have also been associated with increased disease severity and poorer prognosis in dogs with chronic enteropathy and inflammatory bowel disease

Youll have a discussion about the dosage and frequency of injections, as well as any potential side effects or risks associated with them

Vitamin B12 is a water-soluble vitamin absorbed mainly in the small intestine with the help of a protein called intrinsic factor