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3.2 DNA methyltransferase inhibitors in clinical research 3.2.1 Dinucleotide derivant: Guadecitabine Guadecitabine (SGI-110, 5 ) is a dinucleotide derivative of decitabine, which inhibits DNA methylation by the same mechanism of decitabine, but its PK and stability are superior to those of decitabine due to the phosphodiester bond of SGI-110, which can resist the transient degradation of cytidine deaminase

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Liposomaal glutathion is bijzonder effectief voor de behandeling van auto-immuunziekten, waarbij het het lichaam voorziet van een directe bron van GSH om ROS (reactieve zuurstofdeeltjes) te neutraliseren die door ons immuunsysteem worden geproduceerd, en waarbij het de activering van de belangrijke transcriptiefactor NF-B aanzienlijk remt en de productie van TNF- en IL-6 moduleert

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Luftl M, Rocken M, Plewig G, et al

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