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Protocols vary based on the condition being treated acute injuries typically involve a more intensive initial phase, followed by a maintenance dose

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Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose

Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide

More recent data has looked at ways to reduce the body forming antibodies to pegloticase