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Both are dominated by gastrointestinal adverse events nausea, vomiting, diarrhea, constipation, and abdominal pain that are mostly mild to moderate and concentrate during dose escalation

with rosiglitazone (25 mg/kg bw), WY-14643 (12.5 mg/kg bw), or a combination of rosiglitazone (25 mg/kg body weight) and WY-14643 (12.5 mg/kg bw) and cardiac cluster of differentiation ( Cd36 ), lipoprotein lipase ( Lpl ), and angiopoietin like-4 ( Angptl4 ) ( B

Materials and methods Ethics statement All animal experimental procedures in this study were approved and carried out in strict accordance with guidelines for the care and use of animals of the Animal Care and Use Committee at China Agricultural University (approval number CAU20140910-2)

It remains under regulatory review

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