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These enzymes are involved in the reduction of nonspecific connections in protein structures that were subjected to oxidization [18]

Furthermore, histo-densitomentric evaluation of these tumors has recently demonstrated increased human epidermal SOD activity with respect to dermal one, and more expression in human male skin than in female as well as more in young than old people (58)

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This synergistic action was mediated by activation of the Keap1/Nrf2/GPX4 antioxidant axis, which suppressed lipid peroxidation, mitigated ferroptosis, and preserved ovarian function, as evidenced by normalized hormone profiles and follicle counts [160]