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J Diabetes Res (2017) 2017:6483572

[28] Involved subunits [edit] The substrate is coordinated to the zinc and this enzyme has two zinc atoms per subunit

Researchers at the University of Cincinnati, USA, who enrolled 2,129 individuals from 2 independent cohorts, confirmed that plasma TMAO levels are positively correlated with the risk of abdominal aortic aneurysm (AAA) onset and progression and elucidated the mechanism by which gut microbiota-derived TMAO enhances endoplasmic reticulum stress and apoptosis in smooth muscle cells of the aortic wall, leading to the development of AAA in mouse experiments (Benson et al., 2023)