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[0319] As indicated above, in various embodiments, the antibody binds (e.g., specifically binds ALPP and/or ALPPL2 (see, e.g., Fig 1 for ALPP and ALPPL2 sequences)

The defect involves pH-dependent TRPML1-mediated efflux of calcium that activates c-Jun amino-terminal kinase ( JNK)-mediated phosphorylation of dynein intermediate chains, and thereby impedes retrograde motility 19

Back to Journals Drug Design, Development and Therapy Volume 19 Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome Authors Cao Z, Zhou Q, An J , Guo X, Jia X, Qiu Y Received 1 March 2025 Accepted for publication 6 June 2025 Published 18 June 2025 Volume 2025:19 Pages 52555270 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Yan Zhu Zhenzhen Cao, 1, * Qin Zhou, 1, * Jie An, 1, * Xiaojing Guo, 1 XiaoFang Jia, 1 Yuena Qiu 2 1 Department of Gynecology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, 215300, Peoples Republic of China

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