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Wang E, Tan EM, Andreeff M

Methods: We use mathematical models for hepatic glutathione metabolism, including one-carbon metabolism and acetaminophen detoxification, to investigate how the activation of certain enzymes by estradiol leads to dramatic changes in reaction velocities and metabolite concentrations

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The lack of an antitumour effect from the loss of intracellular GSH suggested that extracellular GSH is instead crucial for tumour growth

In addition to being produced within cells, lactate can be secreted between cells through MCTs to participate in the regulation of cellular physiological and pathological processes (99)