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In agreement, human PKU-derived lymphocytes showed a high Phe/Tyr ratio with insufficient mitophagy [125], revealing an intimate relationship between BH4 deficiency and impaired autophagy

Challenges in development of nanoparticle-based therapeutics

These polysaccharides influence lipid metabolism through various pathways, as illustrated in Figure 5

To extend these results and understand whether RSL3 eliminated senescent tumour cells, we used a xenograft model of PC3 prostate cancer cells (Fig

Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial