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XO4 + microglia exhibited dysregulated expression of AD-associated genes, while XO4 microglia showed transcriptional signatures resembling accelerated aging and reduced phagocytic capacity

J Bacteriol 179 , 12801290 (1997)

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Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids

For example, T cell activation upregulates a variety of amino acid transporters, including SLC7A5, and deletion of SLC7A5 leads to activation of the mTOR signaling pathway and upregulation of the transcription factor MYC to inhibit T cell proliferation