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Our results strongly highlight the importance of carefully identifying the optimal ferroptotic mechanism when selecting drugs for combination therapies

3.4 As tolerance through improved antioxidant defense system and reduced uptake A surplus of ROS, such as superoxide radicals (O2 + ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH), is produced when toxic substances are present in plants, leading to oxidative stress (124)

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6.2.1.4 Non-pharmacological interventions Although microglia may express the xCT system, its expression level, functional significance, and impact on overall brain antioxidant status are considerably less pronounced than those in astrocytes