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As such, CRY1 emerges as a pro-tumorigenic factor that rhythmically controls DNA repair mechanisms and cell survival through temporal transcriptional regulation 27

Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a -opioid receptor-dependent manner

Furthermore, it was also found to be more potent than -tocopherol in protecting against H 2 O 2 -induced oxidative stress-related cell death in PC-12 cells (Ochiai et al., 2004b)