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Significantly, the antimalarial potency of these compounds correlated well with their ability to disrupt erythrocyte redox balance in vitro (and slightly less strongly in vivo in mice), leading the authors to conclude that erythrocyte enolase is likely the common target that links these two characteristics

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Other antioxidant strategies include antioxidant mimetics, which are designed to restore antioxidants activity, thus, lowering the impact of oxidative stress in tissue

Metformin use and vitamin B12 deficiency

L-carnitine addresses this problem by encouraging the burning of fats as fuel and also leading glucose to be burned by the mitochondria (instead of being stored as glycogen)