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For females, GPx helps maintain ovarian function by balancing reactive oxygen species essential for ovulation but harmful in excess

The main toxicity provoked is acute liver damage, which is mechanistically provoked by the aberrant adduction of the toxic metabolite N-acetyl p-benzoquinone imine (NAPQI) to cysteinyl residues of key liver proteins [105]

[95] observed that treatment of Shank3 4-22 mice with 7-NI (nNOS inhibitor) resulted in an increase in time spent in the open arms of the elevated plus maze and an enhancement in cognitive behavior, as measured by the novel object recognition test [95]

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The herb kava has caused a number of cases of idiosyncratic liver injury, ranging everywhere from asymptomatic to fatal