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Knockout of MORs from NAc medium spiny neurons (MSN) reduces the ability of MORs to inhibit GABA input to local VTA GABA interneurons in VTA (Charbogne et al., 2017)

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Common additions include: Benzyl alcohol as a preservative in multi-dose vials Buffer solutions to maintain optimal pH (typically around 4.5 to 5.0 for tirzepatide) Mannitol or trehalose as stabilizers in lyophilized formulations These additives affect stability profiles