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Recent studies have found that entacapone reverses ferroptosis and alleviates AKI by inhibiting lipid peroxidation and iron accumulation, with its mechanism involving the regulation of SLC7A11 to enhance antioxidant capacity ( Despite substantial progress in delineating ferroptosis-related mechanisms and potential therapeutics in I/R-induced AKI, critical knowledge gaps and translational bottlenecks persist that limit the clinical utility of these findings and hinder a holistic understanding of disease pathogenesis