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During acute inflammatory conditions, this increase in hemichannel activity may be beneficial for mounting an immune response to an insult, however, the prolonged release of many factors (i.e., glutamate) from astrocytes in chronic conditions may be associated with altered synaptic plasticity and memory impairments (Navarrete and Araque, 2010

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Reference 1.Aquilano K, Baldelli S, Ciriolo MR: Glutathione: new roles in redox signaling for an old antioxidant

For arthritis specifically, it helps reduce pain while encouraging regeneration of connective tissue