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In a study that compared the effects of carbamazepine, venlafaxine, and pregabalin in 257 patients with clinically definite DPN, carbamazepine significantly decreased the VAS score (from 74.5 to 39.6, P =0.0001) and showed similar effects as venlafaxine and pregabalin in improving scores for sleep, mood, and work interference [51]

2013;3:e309

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Consequently, melatonin sensitizes these cells to the extrinsic pathway of apoptosis

CKD induces microbial dysbiosis, which compromises the intestinal mucosal barrier and allows harmful bacteria and uremic toxins to enter the bloodstream