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Nrf2 is responsible for regulating the transcription of many key components within the ferroptosis pathway, 562 and targeting Nrf2 has emerged as a novel strategy for preventing and treating AD

3.65 (95% CI: 3.04.3) and 2.02 (95% CI: 1.162.87), respectively, compared to the PTX group (Fig

Th1 and Th17 cells secrete cytokines that disrupt the tight junctions of the bloodbrain barrier (BBB), allowing inflammatory factors such as TNF, IL-1, and IL-6 to enter the brain, thereby accelerating the progression of AD

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The half-life of free fluorescence labeled Hb was measured use a microplate reader, and the pharmacokinetic results showed that CPTK@PMH could significantly prolong Hb half-life from 12.045 1.251 h to about 35 h