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It was FDA-approved in 1997 under the brand name Geref for growth hormone deficiency in children, administered exclusively as a subcutaneous injection

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No published trial has evaluated the four-peptide KLOW combination together

Dermatologic studies employed concentrations that yielded skin benefits without significant toxicity

Approvals from the European Medicines Agency for several biosimilar somatropins have altered the competitive environment, with hospitals procurement processes becoming more inclined towards using biosimilar drugs