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GSH Among the 20 -amino acids mentioned above, the function of glutamate, glycine, and cysteine metabolism in ferroptosis has attracted more attention

To examine this, conditional myeloid SOCS3 knockout mice (SOCS3MyeKO) with EO771 mammary tumors were developed, demonstrating a significant presence of tumor-infiltrating eMDSCs and enhanced immunosuppression both in vitro and in vivo

This enhances aquaporin-4 expression, ultimately reducing astrocyte viability and causing cellular edema (147, 148)

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