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doi: 10.3390/ani8110189 241 RandallD

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy

The KD group demonstrated improvements in lexical access (F(1,11) = 6.55, p = 0.02, Cohens f = 0.76) and memory (F(1,11) = 8.42, p = 0.01, f = 0.87), as well as a reduction in memory interference (F(1,11) = 4.03, p = 0.06, f = 0.60)

A principal mechanism of action involves the modulation of gene and protein expression governing tight-junction signaling pathways within intestinal IECs, thereby influencing barrier assembly, permeability, and overall epithelial integrity (166)

M2 tumor-associated macrophages-derived exosomal MALAT1 promotes glycolysis and gastric cancer progression