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Mirzadeh K, Martinez V, Toddo S, Guntur S, Herrgard MJ, Elofsson A, Nrholm MH, Daley DO

Filomeni et al., 2005b)

piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

While preconditioned, short, or moderate hypoxic exposures can stimulate repair through angiogenesis, enhanced stemness, and metabolic adaptation, sustained or severe hypoxia may instead promote fibrosis, cellular exhaustion, or maladaptive remodeling [97]

5C, D) suggesting that surprisingly, a major fraction of these SAL-regulated genes are significantly coregulated by AKT in both cell lines (Fig