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This leads to the formation of large, abnormal and immature red blood cells and impaired DNA synthesis

None of the authors received outside funding for the production of this original manuscript and no part of this article has been previously published elsewhere

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4 alkoxy, Ci -4 alkyl, oxo, CN, -(C 0-3 alkyl)-NR 3a R 3 , C 3-7 cycloalkyl and C 3

doi: 10.3389/fimmu.2025.1683876 Received 11 August 2025 Revised 30 October 2025 Accepted 18 November 2025 Published 05 December 2025 Volume 16 - 2025 Edited by Matheus Mattos, KU Leuven, Belgium Reviewed by Hongquan Wang, Peking University Aerospace School of Clinical Medicine, China Hongjian Pu, University of Pittsburgh, United States Yongjuan Xin, Zhengzhou University, China Updates Copyright 2025 Yi, Jia, Xie, Peng, Zhu, Yin, Luo, Deng and Wan