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Acetaldehyde and ROS generated during alcohol metabolism can directly stimulate KCs and HSCs, promoting the transcription and secretion of TNF- [124, 125]

Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury

Future work should include expert-driven evaluations of the identified KERs using the BH criteria, covering aspects such as biological plausibility, essentiality, empirical support (e.g., doseresponse and temporal patterns), and overall coherence across studies